Humanin
aka HN
Mechanism
Humanin is a mitochondrial-derived peptide encoded within the 16S ribosomal RNA gene. It was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity and is studied for neuroprotection, metabolic regulation, and anti-aging applications.
Identification
| CAS number | 330936-69-1 |
|---|---|
| Molecular formula | C119H204N34O32S2 |
| Sequence | MAPRGFSCLLLLTSEILDLPVKRRA |
| Typical dose | 0.5–2 mg subcutaneous injection, daily to 3x weekly (research use only; no established clinical dose) |
| Half-life | ~0.5–4 hours (native humanin: ~5–15 min plasma half-life; HNG analogue has extended activity) |
Vendors selling Humanin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $165.00 | — | 99 |
| Peptide Tech | 10 mg | $103.99 | — | 94 |
| Ruo Bio | 10 mg | $46.00 | — | 88 |
| Simple Peptide | — | $99.00 | — | 85 |
| Peptidegurus | 10 mg | — | — | 84 |
| Biotech Peptides | 10 mg | $140.00 | — | — |
| Core Peptides | 10 mg | $147.00 | — | — |
| Genetic Peptide | 5 mg | $80.00 | — | — |
| Solution Peptides | 10 mg | $69.00 | — | — |
| Wellness Peptides | — | $115.00 | — | — |
Research
Diabetes mellitus is a major metabolic disorder closely associated with oxidative stress and male reproductive dysfunction.
source →Selective serotonin reuptake inhibitors (SSRIs) such as paroxetine frequently induce male sexual dysfunction by disrupting neuroendocrine balance and central dopaminergic pathways.
source →Background Gestational diabetes mellitus (GDM) is characterized by maternal insulin resistance and hyperglycemia and has been associated with placental mitochondrial alterations.
source →In brief: Redox imbalance compromises granulosa cell survival and follicle fate. This study identifies the mitochondrial-derived peptide Humanin (HN) as a cytoprotective factor that protects granulosa cells under oxidative condItions. Abstract: Granulosa cell function is essential for proper ovarian physiology.
source →The present study aimed to assess the presence of humanin in the sperm of crossbred cattle bulls using immunocytochemistry and to evaluate its potential as a semen quality marker.
source →Objective : Diabetes mellitus is closely associated with mitochondrial dysfunction, which disrupts cellular energy metabolism and perturbs hormonal homeostasis.
source →This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression in Royal College of Surgeons (RCS) rats with retinal pigment epithelium (RPE) dysfunction and retinal degeneration.
source →Diabetes mellitus (DM) markedly increases the risk of cardiovascular complications through mechanisms involving hyperglycemia-induced oxidative stress, inflammation, and apoptosis.
source →Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with limited therapeutic options. S14G-humanin (HNG), a potent analog of humanin, exerts protective effects in various diseases, but its role in DN remains unexplored.
source →Recent investigations show that mitochondrial impairment significantly contributes to endothelial damage in septic acute respiratory distress syndrome (ARDS).
source →Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes.
source →Background The health benefits of the Mediterranean Diet (Med-Diet) have been demonstrated in observational studies and randomized controlled trials. Emerging evidence suggests that the biological effects of the Med-Diet may be mediated by the modulation of mitochondrial function.
source →This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group
source →The goal of this observational study is to assess the clinical value of humanin in acute kidney injury.
source →The goal of this observational study is to explore the value of Humanin for early diagnosis and short-term prognosis of AKI patients after heart transplantation.
source →1. To investigate the circulating concentrations of phoenixin and their associations with BMI, the concentrations of sex hormones including (LH), (FSH), (E2), (P4), (TT) and steroid hormones enzyme in PCOS patients. 2.
source →Objective of the study is to clarify humanin-like peptide concentration in myocard tissue and in blood and to study if its concentration level is related to early complication occurrence and frequency after cardiac operation. Hypothesis of the study is that previously described elements are related to each other.
source →* Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to contractures, bony deformations, difficulty to walk and impaired manual ability.
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