MGF
aka Mechano Growth Factor · IGF-1Ec · IGF-1 Ec
Mechanism
Mechano Growth Factor is the C-terminal E-domain peptide derived from IGF-1Ec, a splice variant of insulin-like growth factor 1 that is expressed locally and transiently in skeletal muscle in response to mechanical loading or damage. After cleavage from the IGF-1 precursor, the 24-amino-acid MGF E-peptide acts independently of the IGF-1 receptor, helping activate quiescent satellite (muscle stem) cells to support muscle repair and hypertrophy. Synthetic MGF is the unmodified peptide and is degraded rapidly in body fluids; the related PEG-MGF kept in this directory is the pegylated form, in which polyethylene glycol (and typically a stabilizing D-amino-acid substitution) is attached to extend half-life. MGF is not FDA-approved and is a grey-market research compound with no controlled human efficacy data.
Studied uses
- muscle growth and recovery research (research only)
- satellite-cell activation studies (preclinical)
- experimental tissue repair (research only)
Identification
| Sequence | YQPPSTNKNTKSQRRKGSTFEERK |
|---|---|
| Typical dose | Vendor-reported research use commonly 100-200 mcg per injection, local/subcutaneous; no validated human dosing |
| Half-life | Very short (minutes-scale) for unmodified MGF due to rapid degradation in plasma; the pegylated PEG-MGF variant is engineered for a substantially longer half-life |
Safety
Not FDA-approved for human use; sold as a research chemical only with no controlled human safety data. As an IGF-1-related growth factor it is prohibited at all times under the WADA Code (S2). Theoretical risks include effects on cell proliferation; purity and identity of grey-market product are unverified.
Vendors selling MGF
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Simple Peptide | 5 mg | $66.00 | — | 85 |
| Simple Peptide | 2 mg | $39.00 | — | 85 |
| AMC Essentials | 2 mg | $29.99 | — | — |
| Alpha Omega | 5 mg | $66.00 | — | — |
| Biotech Peptides | 5 mg | $59.00 | — | — |
| Core Peptides | 5 mg | $145.00 | — | — |
| Core Peptides | 5 mg | $50.00 | — | — |
| Genetic Peptide | 10 mg | $90.00 | — | — |
| Paramount Peptides | 5 mg | $127.50 | — | — |
Research
Natural products exhibiting spontaneous vesicular self-assembly are rare. Mangiferin, a natural xanthonoid, was isolated from the rhizome of the fern Davallia solida . Herein, we demonstrate that mangiferin spontaneously self-assembles in aqueous and organic-aqueous binary solutions, forming stable spherical vesicles.
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