P21
aka P021
Mechanism
P21 (also P021) is a small peptidergic compound — the tetrapeptide core Asp-Gly-Gly-Leu with an N-terminal acetyl and a C-terminal adamantylated glycine amide (Ac-DGGL(A)G-NH2) — derived from an active region (residues ~148–151) of human ciliary neurotrophic factor (CNTF). It was designed and characterized in the Khalid Iqbal laboratory at the New York State Institute for Basic Research in Developmental Disabilities (NYS IBR). It is an experimental, preclinical compound — NOT FDA-approved and NOT tested in humans in published trials. Distinct from the cyclin-dependent kinase inhibitor protein p21/CDKN1A/WAF1 (a completely different gene product; the two share only the name).
Identification
| CAS number | 1246751-68-7 |
|---|---|
| Molecular formula | C27H42N6O8 |
| Sequence | DGGL |
| Typical dose | 500–750 mcg/day intranasal (research use); 250–1000 mcg/day range reported |
| Half-life | >6 hours (rodent; estimated, based on parent Peptide 6 and adamantane-modified stability) |
Vendors selling P21
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Skye Peptides | 10 mg | $79.00 | — | 90 |
| Verified Peptides | 10 mg | $119.00 | — | 86 |
| Simple Peptide | 10 mg | $198.00 | — | 85 |
| Peptidegurus | 5 mg | — | — | 84 |
| Alpha Omega | 10 mg | $198.00 | — | — |
| Core Peptides | 5 mg | $116.00 | — | — |
| Genetic Peptide | 5 mg | $120.00 | — | — |
| Paramount Peptides | 10 mg | $127.50 | — | — |
| realpeptides.co | — | $100.00 | — | — |
Research
Introduction CDKN1A (encoding p21) is a canonical regulator of cell cycle arrest and genomic stability. However, its functional spectrum within the tumor microenvironment (TME), especially at single-cell resolution, remains insufficiently defined.
source →Background Unexplained miscarriage (UM) highly occurs and largely limits human reproduction. Cellular senescence is a ubiquitous process that is associated with many human diseases.
source →Introduction The t(2;11)(p21;q23) translocation without KMT2A rearrangement has been reported in ~16 hematologic neoplasms, but its molecular target(s) remain unknown. We aimed to identify the genes disrupted by this translocation and to clarify its contribution to Acute Myeloid Leukemia (AML) pathogenesis.
source →The CRISPR/Cas9 method facilitates targeted disruption of gene sequences, providing a reliable means to analyze gene-dependent regulatory pathways. This study aims to investigate melanogenesis in p21-knockout B16F1 cells generated by the CRISPR/Cas9 system.
source →The cell cycle orchestrates the events that lead to cell replication and division. AMBRA1 interacts with the E3 ubiquitin ligase CRL4DDB1 complex to regulate the stability of D-type cyclins, key regulators of the G1-S phase transition. However, whether AMBRA1 has a role in the S phase remains to be elucidated.
source →Cellular senescence plays key roles in tissue repair, tumour suppression and ageing. Here we identify a rapid, transcription‑independent senescence response in skin following injury. Within minutes to hours after wounding, skin cells at the edge of injury display hallmark features of senescence.
source →Osteoarthritis (OA) is a disease characterized by progressive cartilage degeneration. P21, as a cell cycle regulator, participates in maintaining cartilage homeostasis.
source →p21 (Cip1/Waf1/Sdi1) , a widely studied member of the CKI (CDK inhibitor) family, has been designated a negative regulator of cell cycle progression.
source →Skeletal muscle differentiation relies on transient DNA strand breaks (DSBs), yet excessive DNA damage remains harmful to myogenic progression.
source →Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic efficacy and severe side effects associated with conventional chemotherapy, creating an urgent need for safe and effective natural anti-tumor agents.
source →Emerging evidence has established that renal tubular epithelial cell (TEC) senescence is an essential driver of renal fibrosis, while the activation of p53/p21 pathway plays a key role in initiating TEC senescence.
source →The goal of this study is to test the maximum tolerated dose of ACU-D1 in HIV-positive people with HPV-associated vulvar and perianal lesions.
source →This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension (SAH), in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will…
source →Presbyopia-correcting implant (PC-IOL): AcrySof IQ Vivity (Alcon) has been evaluated in 2 large pivotal trials (US and OUS trials). These tests showed that this PC-IOL restored intermediate visual acuity (IVA) and near visual acuity (NV A) superior to that of the reference monofocal AcrySof implant.
source →Cisplatin-combination chemotherapy causes inevitably DNA damage by platinum-DNA adduct formation of both tumor cells but also healthy cells.
source →This study will evaluate whether the addition of Rosuvastatin to standard chemoradiation therapy for the treatment of locally advanced rectal cancer may improve the pathological response rate and survival compared to standard chemoradiation therapy alone.
source →Bedside ultrasonographic assessment of IVC size and IVC collapsibility index can be used to guide the management of patients with acute kidney injury with and without volume overload in the intensive care unit
source →The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular dystrophy, Myotonia, MH).
source →The purpose of this study is to assess the maximum tolerated dose of low-dose radiation in combination with Docetaxel in recurrent or metastatic non-small cell lung cancer for second-line therapy.
source →