Oxytocin
aka Pitocin (IV obstetric)
Mechanism
Oxytocin is a nine-amino acid peptide hormone (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2, with a disulfide bridge between Cys1 and Cys6) produced in the hypothalamic paraventricular and supraoptic nuclei. The synthetic form (Pitocin) is FDA-approved as IV/IM injection for labor induction/augmentation and postpartum hemorrhage control. Intranasal oxytocin is NOT FDA-approved and is used off-label or in research settings for social/behavioral indications, where evidence is mixed.
Identification
| CAS number | 50-56-6 |
|---|---|
| Molecular formula | C43H66N12O12S2 |
| Sequence | CYIQNCPLG |
| Typical dose | 24 IU intranasal per administration (common research dose); 24-40 IU intranasal studied in clinical trials; IV obstetric use (Pitocin) is weight/indication-based and distinct from research protocols |
| Half-life | ~3-5 minutes (IV, peripheral plasma) |
Vendors selling Oxytocin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Glacier Aminos | 10 mg | $55.99 | — | 99 |
| Moglabs | 5 mg | $24.00 | — | 96 |
| BioLongevity Labs | 10 mg | $64.97 | — | 96 |
| Orbitrex Peptides | 2 mg | $29.99 | — | 95 |
| Profound Aminos | 5 mg | $39.00 | — | 95 |
| Licensed Peptides | 10 mg | $76.99 | — | 95 |
| Peptide Tech | — | $28.99 | — | 94 |
| Mile High Compounds | — | $59.99 | — | 94 |
| Riptide Wellness | — | $44.99 | — | 92 |
| Peptidology | 10 mg | $42.99 | — | 89 |
| Peptide Plugs | — | $45.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | 10 mg | $35.00 | — | 86 |
| EZ Peptides | 10 mg | $58.00 | — | 85 |
| Simple Peptide | 2 mg | $35.00 | — | 85 |
| Simple Peptide | 10 mg | $35.00 | — | 85 |
| Peptidegurus | 10 mg | — | — | 84 |
| Ascension Peptides | 2 mg | $49.99 | — | 83 |
| Blank Peptides | 5 mg | $60.00 | — | 81 |
| Certified Peptides | 10 mg | $52.00 | — | 61 |
| Peptiatlas | — | — | — | 51 |
| HongDa Peptide | — | $29.00 | — | 43 |
| zztai Peptide Ltd | 2 mg | $28.00 | — | 43 |
| zztai Peptide Ltd | 5 mg | $64.00 | — | 43 |
| MJT peptides | 2 mg | $38.00 | — | 39 |
| Kimera Chems | — | $36.99 | — | — |
| Welli Labs | — | $54.99 | — | — |
| Alpha Omega | 2 mg | $35.00 | — | — |
| Alpha Omega | 10 mg | $35.00 | — | — |
| Atomik Labz | 5 mg | $34.00 | — | — |
| Biotech Peptides | 10 mg | $45.00 | — | — |
| Bulk Peptides | 5 mg | $120.00 | — | — |
| Core Peptides | 10 mg | $52.00 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | — | $99.00 | — | — |
| Genetic Peptide | 2 mg | $20.00 | — | — |
| Genetic Peptide | 5 mg | $20.00 | — | — |
| Genetic Peptide | 10 mg | $20.00 | — | — |
| Modern Research Peptides | 5 mg | $35.99 | — | — |
| Modern Research Peptides | 2 mg | $29.99 | — | — |
| Oneday Compounds | 5 mg | $29.24 | — | — |
| Paramount Peptides | 10 mg | $55.25 | — | — |
| Peptide Crafters | 5 mg | $45.00 | — | — |
| Peptira | — | $34.00 | — | — |
| Solution Peptides | 5 mg | $34.00 | — | — |
| Soma Peptides | — | $139.00 | — | — |
| Soma Peptides | 2 mg | $49.00 | — | — |
| True Peptide | 5 mg | $34.00 | — | — |
| realpeptides.co | — | $70.00 | — | — |
Research
Background loneliness, whether social or emotional, is a significant public health issue due to its substantial impact on physical and mental health.
source →Introduction Oxytocin is widely used to augment uterine contractions during labor. However, its use has been associated with fetal heart rate (FHR) abnormalities and neonatal morbidity, which may be reduced by discontinuing oxytocin during labor.
source →Chronic social isolation and loneliness are associated with several neuropsychiatric disorders including depression and anxiety. Given its ability to modulate a wide range of processes linked to social interactions, the therapeutic potential of the neuropeptide oxytocin has gathered interest.
source →The rewarding effects of psychostimulants are strongly influenced by social context, yet the underlying neurochemical and neuropeptidergic mechanisms remain unclear. This study examined the role of oxytocin (OT) and vasopressin (AVP) in context-dependent reward induced by subchronic mephedrone treatment in rats.
source →Oxytocin is a putative pharmacological target for social dysfunction. However, clinical trials of intranasal oxytocin have produced modest and inconsistent effects, motivating the search for naturalistic, non-pharmacological ways to recruit endogenous oxytocin.
source →Oxytocin is a nine-amino-acid peptide hormone renowned for its roles in reproduction and childbirth. Beyond these classical functions, it has attracted increasing research interest for its broader biological activities.
source →People with narcolepsy have intrusive episodes of muscle weakness known as cataplexy, which are usually triggered by strong, positive emotions. As cataplexy occurs almost exclusively during social interactions, we examined whether it is promoted by the prosocial neuropeptide oxytocin.
source →Clinical evidence indicates that tactile stimulation of the skin, such as stroking or gentle touch, elicits a range of beneficial physiological and psychological responses, such as increased social interaction, wellbeing, calm, restorative and growth promoting effects, as well as reduced fear, pain, and stress levels.
source →Salivary oxytocin is a widely used peripheral measure for investigating neuroendocrine correlates of social, stress-related, and adaptive physiological processes.
source →Background The neuropeptide oxytocin offers a potentially effective treatment for alcohol use disorder (AUD). Acting centrally in the brain, oxytocin mediates a range of behavioral effects, including reward, stress response, social affiliation, learning, memory, and addictive behaviors.
source →Background Postpartum hemorrhage remains a major cause of maternal morbidity, and cesarean delivery is associated with greater blood loss than vaginal birth.
source →The aim of this clinical trial is to test if carbetocin is as effective as oxytocin plus misoprostol in decreasing intraoperative blood loss in women undergoing planned cesarean section.
source →The main aim of the study is to investigate whether orally administered oxytocin (24IU) could modulate attention control using a social-emotional saccade/antisaccade eye-tracking paradigm.
source →Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality worldwide. Successful management of postpartum hemorrhage requires not only administration of the right medicine, but also a rapid and coordinated response from a multi-professional team.
source →Purpose to evaluates the effects of oxytocin infusion with or without intravenous tranexamic acid (TA) in comparison with Carbetocin for prevention of postpartum hemorrhage at a cesarean section with one or more risk factor for postpartum hemorrhage.
source →Background Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide accounting for 25% of maternal deaths. In Zimbabwe PPH is the second most common cause of death. Tranexamic acid (TXA) is widely used to reduce blood loss in elective surgery, bleeding trauma patients, and menorrhagia.
source →To test efficacy and safety of a novel nasal spray of oxytocin on social deifies in autism spectrum disorder, and To compare effect sizes of different doses
source →In a randomized control trial conducted in six study centers/labour wards in Sweden, consenting nulliparous women in active phase of labour and with a defined delayed labour progress will be randomized to receive a regimen of either high or low dose of oxytocin. Primary outcome is caesarean delivery rate.
source →This study compares two community-level strategies: selective administration of 800 mcg sublingual misoprostol to women at 350 mL blood loss for secondary prevention of postpartum hemorrhage (PPH) with universal use of 600 mcg oral misoprostol at the time of delivery for primary prevention of PPH.
source →Oxytocin is an essential lactation hormone released during breastfeeding that causes milk ejection and appears to have calming effect on the mother.[1] Administration of exogenous oxytocin to mothers having difficulty in breastfeeding has not been clearly shown to have a beneficial effect on lactation success or in the…
source →