Retatrutide

aka Retatrutide (LY3437943 — GLP-1/GIP/Glucagon triple agonist)

GLP-1 / Metabolic

Mechanism

Retatrutide (Eli Lilly code LY3437943) is an investigational triple-receptor agonist simultaneously targeting GLP-1, GIP, and glucagon receptors. It is research-only and NOT FDA-approved as of April 2026; the Phase 3 TRIUMPH program is ongoing with anticipated NDA filing in 2026. Published Phase 2 data showed roughly 24% mean body weight loss at 48 weeks on 12 mg weekly (Jastreboff, NEJM 2023).

Identification

CAS number	2381089-83-2
Molecular formula	C221H342N46O68
Sequence	`YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS`
Typical dose	0.5–12 mg once weekly subcutaneous (Phase 2 titration; 2–8 mg most studied maintenance range)
Half-life	~6 days

Vendors selling Retatrutide

Vendor	Size	Price	Listed purity	Trust
Peptide Partners	48 mg	$273.00	—	99
Crush Research	20 mg	$76.33	—	95
Crush Research	50 mg	$116.33	—	95
Crush Research	10 mg	$129.00	—	95
Crush Research	15 mg	$199.00	—	95
Crush Research	30 mg	$249.00	—	95
Orbitrex Peptides	10 mg	$79.99	—	95
Orbitrex Peptides	20 mg	$129.99	—	95
Orbitrex Peptides	30 mg	$210.00	—	95
Orbitrex Peptides	36 mg	$219.99	—	95
Profound Aminos	5 mg	$69.00	—	95
Prime Peptides	10 mg	$120.00	—	95
Prime Peptides	30 mg	$120.00	—	95
Prime Peptides	60 mg	$120.00	—	95
Amino Club	30 mg	$179.99	—	93
Skye Peptides	12 mg	$90.00	—	90
Qihang Peptide	—	—	—	87
Peptidegurus	10 mg	—	—	84
Peptidegurus	20 mg	—	—	84
Peptidegurus	30 mg	—	—	84
Reta Peptide	10 mg	$135.00	—	83
Cocer Peptides	10 mg	$200.00	—	82
Cocer Peptides	30 mg	$430.00	—	82
Cocer Peptides	40 mg	$480.00	—	82
Cocer Peptides	50 mg	$580.00	—	82
Blank Peptides	10 mg	$130.00	—	81
Blank Peptides	20 mg	$130.00	—	81
Blank Peptides	30 mg	$130.00	—	81
Crystal Peptides	10 mg	$99.00	—	66
Crystal Peptides	20 mg	$159.99	—	66
Crystal Peptides	30 mg	$199.00	—	66
Peptiatlas	—	—	—	51
Peptiatlas	—	—	—	51
Taishijie	—	—	—	51
Taikangbio	—	—	—	50
Zjpeptix	—	—	—	50
Hkuppeptide	10 mg	$10.00	—	50
Hkuppeptide	—	$10.00	—	50
Hkuppeptide	10 mg	$10.00	—	50
Hkuppeptide	5 mg	$10.00	—	50
Hkuppeptide	15 mg	$10.00	—	50
Hkuppeptide	10 mg	$10.00	—	50
MEI-PEPETIDE	5 mg	$120.00	—	48
DongCheng Peptide	—	—	—	46
Mandy	5 mg	$45.00	—	43
HongDa Peptide	—	$77.00	—	43
zztai Peptide Ltd	5 mg	$110.00	—	43
zztai Peptide Ltd	10 mg	$170.00	—	43
zztai Peptide Ltd	15 mg	$206.00	—	43
zztai Peptide Ltd	20 mg	$240.00	—	43
zztai Peptide Ltd	30 mg	$280.00	—	43
MJT peptides	5 mg	$70.00	—	39
HK Peptide Ltd (hk peptides)	10 mg	$145.00	—	37
Alpha Peptides	—	—	—	—
Cernum Biosciences	5 mg	$94.99	—	—
Cernum Biosciences	10 mg	$94.99	—	—
Cernum Biosciences	15 mg	$94.99	—	—
Cernum Biosciences	20 mg	$94.99	—	—
NG Peptide	10 mg	$42.00	—	—
Strate Labs	60 mg	$299.00	—	—
Bulk Peptides	20 mg	$600.00	—	—
Bulk Peptides	10 mg	$360.00	—	—
Polaris Peptides	60 mg	$400.00	—	—
Polaris Peptides	10 mg	$89.00	—	—
Polaris Peptides	35 mg	$275.00	—	—
Polaris Peptides	5 mg	$50.00	—	—
Polaris Peptides	15 mg	$130.00	—	—
realpeptides.co	—	$130.00	—	—

Research

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats

Keskin U, Altın E, Kara MK, Tekin B, Çakırçoban KN, Özatik FY, Arı NS, Sezgin AK, Güngor E. · Behavioural brain research (2026) · animal

Diabetes mellitus is associated with cognitive impairment and neurodegenerative changes, partly through hyperglycaemia-driven neuroinflammation and disrupted neuronal signalling.