Sermorelin
aka Geref
Mechanism
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of the 44-aa native hormone — the shortest fragment that retains full biological activity. It was FDA-approved in the 1990s as Geref (EMD Serono) for diagnostic testing of pituitary GH reserve and later for pediatric idiopathic GH deficiency, but was withdrawn from the US market in 2008–2009 at the manufacturer's request for commercial reasons (not safety or efficacy). It remains on the FDA Category 1 list of bulk substances nominated for use in 503A compounding, where it is now widely prescribed off-label for adult GH insufficiency and "anti-aging" indications.
Identification
| CAS number | 86168-78-7 |
|---|---|
| Molecular formula | C149H246N44O42S |
| Sequence | YADAIFTNSYRKVLGQLSARKLLQDIMSR |
| Typical dose | 200-500 mcg/day subcutaneous injection, typically administered at bedtime |
| Half-life | ~10-20 minutes (plasma elimination half-life after subcutaneous administration) |
Vendors selling Sermorelin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $115.00 | — | 99 |
| Glacier Aminos | 10 mg | $62.99 | — | 99 |
| Crush Research | 10 mg | $43.00 | — | 95 |
| Orbitrex Peptides | 10 mg | $79.99 | — | 95 |
| Profound Aminos | 5 mg | $43.00 | — | 95 |
| Licensed Peptides | 5 mg | $404.95 | — | 95 |
| Licensed Peptides | 5 mg | $68.99 | — | 95 |
| Licensed Peptides | 10 mg | $68.99 | — | 95 |
| Prime Peptides | 10 mg | $65.00 | — | 95 |
| Peptide Tech | 5 mg | $33.99 | — | 94 |
| Mile High Compounds | — | $69.99 | — | 94 |
| Ignite Peptides | 10 mg | $80.00 | — | 92 |
| Ignite Peptides | 5 mg | $50.00 | — | 92 |
| Hydro Research Peptides | 10 mg | $0.64 | — | 91 |
| Skye Peptides | 5 mg | $49.00 | — | 90 |
| Peptidology | 10 mg | $79.95 | — | 89 |
| Peptide Plugs | 10 mg | $55.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| EZ Peptides | 5 mg | $44.00 | — | 85 |
| Simple Peptide | 5 mg | $49.00 | — | 85 |
| Simple Peptide | 10 mg | $49.00 | — | 85 |
| Peptidegurus | 2 mg | — | — | 84 |
| Peptidegurus | 5 mg | — | — | 84 |
| Ascension Peptides | 10 mg | $72.00 | — | 83 |
| Blank Peptides | 10 mg | $70.00 | — | 81 |
| OROS Research | 10 mg | $59.99 | — | 79 |
| OROS Research | 5 mg | $44.99 | — | 79 |
| Texpeptide | 10 mg | $50.00 | — | 69 |
| Crystal Peptides | 10 mg | $59.99 | — | 66 |
| Certified Peptides | 10 mg | $95.00 | — | 61 |
| Certified Peptides | 5 mg | $60.00 | — | 61 |
| Sports Technology Labs | 5 mg | $51.99 | — | 58 |
| Nox Amino | 10 mg | $55.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| MEI-PEPETIDE | 2 mg | $32.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $56.00 | — | 43 |
| HongDa Peptide | — | $80.00 | — | 43 |
| MJT peptides | 5 mg | $73.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | — | — | — | 37 |
| Nextech Labs | 10 mg | $75.00 | — | 24 |
| Cernum Biosciences | 5 mg | $52.99 | — | — |
| Cernum Biosciences | 10 mg | $79.99 | — | — |
| NG Peptide | 10 mg | $45.00 | — | — |
| Strate Labs | 10 mg | $99.95 | — | — |
| Kimera Chems | — | $46.99 | — | — |
| Welli Labs | — | $54.99 | — | — |
| synthesispeptides.io | 10 mg | $74.99 | — | — |
| AMC Essentials | 10 mg | $65.99 | — | — |
| Alpha Omega | 5 mg | $49.00 | — | — |
| Alpha Omega | 10 mg | $49.00 | — | — |
| Atomik Labz | 10 mg | $74.00 | — | — |
| Atomik Labz | 10 mg | $64.00 | — | — |
| Biotech Peptides | 9 mg | $88.00 | — | — |
| Biotech Peptides | 5 mg | $43.00 | — | — |
| Biotech Peptides | 10 mg | $81.00 | — | — |
| Core Peptides | 9 mg | $85.00 | — | — |
| Core Peptides | 10 mg | $88.00 | — | — |
| Core Peptides | 10 mg | $88.00 | — | — |
| Core Peptides | 10 mg | $80.00 | — | — |
| Core Peptides | 5 mg | $48.00 | — | — |
| Felix Chemical Supply | 10 mg | $69.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 5 mg | $55.00 | — | — |
| Genetic Peptide | 10 mg | $165.00 | — | — |
| Genetic Peptide | 10 mg | $95.00 | — | — |
| Genetic Peptide | 9 mg | $95.00 | — | — |
| Genetic Peptide | 2 mg | $35.00 | — | — |
| Genetic Peptide | 18 mg | $200.00 | — | — |
| Modern Research Peptides | 5 mg | $39.99 | — | — |
| Modern Research Peptides | 10 mg | $46.99 | — | — |
| Nova Peptides | 5 mg | $49.99 | — | — |
| Paramount Peptides | 10 mg | $68.00 | — | — |
| Peptide Crafters | 5 mg | $25.00 | — | — |
| Peptide Crafters | 5 mg | $55.00 | — | — |
| Peptide Crafters | 10 mg | $55.00 | — | — |
| Pepvida Labs | 13 mg | $79.00 | — | — |
| Polaris Peptides | 10 mg | $75.00 | — | — |
| S1 Research | 5 mg | $30.00 | — | — |
| S1 Research | 10 mg | $30.00 | — | — |
| Solution Peptides | 10 mg | $74.00 | — | — |
| Solution Peptides | 10 mg | $64.00 | — | — |
| Soma Peptides | 10 mg | $69.00 | — | — |
| Southern Aminos | 10 mg | $58.80 | — | — |
| Wellness Peptides | — | $55.00 | — | — |
| optimasupply.is | 10 mg | $64.00 | — | — |
| realpeptides.co | — | $60.00 | — | — |
Research
Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis.
source →Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance enhancement.
source →The pursuit of pharmacological enhancement in sport has evolved from the widespread use of anabolic-androgenic steroids (AAS) to novel agents such as peptides and peptide analogues.
source →Background Anterior cervical osteophytes can compress the esophagus, producing dysphagia. Although common on imaging in older adults, symptomatic osteophytic dysphagia is underdiagnosed, and the role of systemic anabolic factors in osteophyte growth is poorly characterized.
source →Growth hormone-releasing hormone (GHRH) and its synthetic analogs are considered performance-enhancing substances and are therefore prohibited by the World Anti-Doping Agency (WADA).
source →Background Injectable peptides are increasingly promoted for musculoskeletal recovery, tissue repair, and performance enhancements; however, clinical adoption has outpaced high-quality evidence and regulatory consensus.
source →Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →Background Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients.
source →Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →This randomized, double-blind, placebo-controlled Phase II study evaluates whether daily subcutaneous tesamorelin (a growth hormone-releasing hormone analog) reduces liver fat in adults with fatty liver disease.
source →GHRH antagonists (GHRHAnt) were developed to suppress cancers and have been associated with robust anti-inflammatory and anti-oxidative activities. The mechanisms involved in those effects are not completely understood.
source →The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization.
source →The use of growth hormone-releasing hormones (GHRHs) is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA). Considering the complexity of urine samples and the low concentrations at which these analytes should be detected, analyzing GHRHs is a challenging task.
source →Matrix effect and sample pretreatment significantly affect the percentage recovery of peptides in biological matrices, affecting the method robustness and accuracy. To counteract this effect, an internal standard (IS) is used; however, in most cases this is not available, which limits the analytical method.
source →Nonalcoholic fatty liver disease (NAFLD) is common in individuals with obesity and is a significant threat to public health, because it can lead to impaired liver function and liver failure. Growth hormone is a hormone produced in the pituitary gland that helps regulate metabolism and growth.
source →Liver disease is one of the leading co-morbidities of human immunodeficiency virus (HIV) infection, and nonalcoholic fatty liver disease (NAFLD) is present in approximately 30-40% of patients with HIV infection.
source →The purpose of this trial is to examine the short-term effects of Growth Hormone Releasing Hormone (GHRH, tesamorelin) administration in healthy men. We hypothesize that GHRH will increase GH pulse height and will not affect insulin sensitivity.
source →The primary objective of the study is to determine the PK (tesamorelin) and PD (IGF-1) profiles of tesamorelin after a single 2 mg subcutaneous administration and after repeated administration once daily for 14 consecutive days.
source →This protocol will assess the cardiovascular risk associated with growth hormone deficiency in adults.
source →OBJECTIVES: I. Determine whether release of endogenous growth hormone (GH)-releasing hormone is involved in GH responses to clonidine, pyridostigmine, levodopa, arginine, GH-releasing peptide, insulin-induced hypoglycemia, and exercise in patients with acromegaly. II.
source →