KPV
aka Lysine-Proline-Valine (alpha-MSH 11-13)
Mechanism
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (alpha-MSH), corresponding to residues 11-13. It is the smallest alpha-MSH fragment shown to retain anti-inflammatory activity. Research-only; not FDA-approved; evidence is primarily preclinical.
Identification
| CAS number | 67727-97-3 |
|---|---|
| Molecular formula | C16H30N4O4 |
| Sequence | KPV |
| Typical dose | 250–500 mcg/day subcutaneous (research use) |
| Half-life | ~4–6 hours (rodent pharmacokinetic data; human data lacking) |
Vendors selling KPV
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $88.00 | — | 99 |
| Glacier Aminos | 10 mg | $51.99 | — | 99 |
| Moglabs | 5 mg | $30.00 | — | 96 |
| BioLongevity Labs | 10 mg | $99.97 | — | 96 |
| Crush Research | 10 mg | — | — | 95 |
| Orbitrex Peptides | — | $69.99 | — | 95 |
| Ion Peptide | 10 mg | $49.00 | — | 95 |
| Licensed Peptides | 10 mg | $449.95 | — | 95 |
| Licensed Peptides | 10 mg | $76.99 | — | 95 |
| Peptide Tech | 10 mg | $38.99 | — | 94 |
| Mile High Compounds | — | $49.99 | — | 94 |
| Mile High Compounds | — | $109.99 | — | 94 |
| Mile High Compounds | — | $149.99 | — | 94 |
| Amino Club | — | $39.99 | — | 93 |
| Ignite Peptides | 10 mg | $30.00 | — | 92 |
| Riptide Wellness | — | $65.99 | — | 92 |
| Hydro Research Peptides | 10 mg | $0.55 | — | 91 |
| Skye Peptides | 10 mg | $44.00 | — | 90 |
| Peptidology | 10 mg | $42.99 | — | 89 |
| Peptide Plugs | 10 mg | $40.00 | — | 89 |
| Peptide Plugs | — | $120.00 | — | 89 |
| Ruo Bio | — | $48.00 | — | 88 |
| Sunrise Bioresearch | 50 mg | $139.70 | — | 88 |
| Sunrise Bioresearch | 10 mg | $28.22 | — | 88 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | 10 mg | $55.00 | — | 86 |
| EZ Peptides | 10 mg | $44.00 | — | 85 |
| Simple Peptide | 10 mg | $45.00 | — | 85 |
| Peptidegurus | 5 mg | — | — | 84 |
| Ascension Peptides | 10 mg | $50.00 | — | 83 |
| Cocer Peptides | 10 mg | $100.00 | — | 82 |
| Cocer Peptides | 30 mg | $220.00 | — | 82 |
| Blank Peptides | 10 mg | $45.00 | — | 81 |
| OROS Research | 15 mg | $74.99 | — | 79 |
| Texpeptide | 10 mg | $55.00 | — | 69 |
| Crystal Peptides | 10 mg | $44.98 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 10 mg | $76.00 | — | 61 |
| Sports Technology Labs | 5 mg | $51.99 | — | 58 |
| Nox Amino | 10 mg | $55.00 | — | 55 |
| Puratek Peptides | 10 mg | $34.95 | — | 44 |
| Mandy | 10 mg | $45.00 | — | 43 |
| HongDa Peptide | — | $74.00 | — | 43 |
| Nextech Labs | 10 mg | $55.00 | — | 24 |
| Alpha Peptides | — | — | — | — |
| NG Peptide | 10 mg | $35.00 | — | — |
| Strate Labs | 10 mg | $69.95 | — | — |
| Kimera Chems | — | $31.99 | — | — |
| Welli Labs | — | $28.99 | — | — |
| synthesispeptides.io | — | $57.99 | — | — |
| AMC Essentials | 10 mg | $39.99 | — | — |
| Alpha Omega | 10 mg | $45.00 | — | — |
| Atomik Labz | 10 mg | $55.00 | — | — |
| Atomik Labz | 10 mg | $64.00 | — | — |
| Biotech Peptides | 4 mg | $39.00 | — | — |
| Bulk Peptides | — | $130.00 | — | — |
| Bulk Peptides | 5 mg | $160.00 | — | — |
| Core Peptides | 4 mg | $38.00 | — | — |
| Felix Chemical Supply | 10 mg | $79.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | — | $149.00 | — | — |
| Genetic Peptide | 5 mg | $55.00 | — | — |
| Lumi Peptides | — | $38.00 | — | — |
| Modern Research Peptides | 10 mg | $39.99 | — | — |
| Nova Peptides | — | $79.99 | — | — |
| Nova Peptides | 10 mg | $49.99 | — | — |
| Oasis Labs | 10 mg | $47.00 | — | — |
| Oneday Compounds | 10 mg | $34.44 | — | — |
| Paramount Peptides | 10 mg | $62.90 | — | — |
| Peptide Crafters | 20 mg | $80.00 | — | — |
| Peptide Crafters | 10 mg | $40.00 | — | — |
| Peptira | — | $119.00 | — | — |
| Peptira | — | $49.00 | — | — |
| Pepvida Labs | 16 mg | $75.00 | — | — |
| Platinum Lion | — | $39.99 | — | — |
| Polaris Peptides | 10 mg | $55.00 | — | — |
| S1 Research | 10 mg | $30.00 | — | — |
| Solution Peptides | 10 mg | $64.00 | — | — |
| Solution Peptides | 10 mg | $55.00 | — | — |
| Soma Peptides | 10 mg | $119.00 | — | — |
| Southern Aminos | 10 mg | $34.30 | — | — |
| True Peptide | 10 mg | $80.00 | — | — |
| Wellness Peptides | — | $45.00 | — | — |
| idunpeptides.com | — | $24.99 | — | — |
| optimasupply.is | 10 mg | $55.00 | — | — |
| realpeptides.co | — | $85.00 | — | — |
Research
Hepatocellular steatosis, an early stage within the non-alcoholic fatty liver disease (NAFLD) spectrum, is characterized by excessive lipid accumulation and oxidative stress in hepatocytes.
source →Introduction The development of novel quinolin-2(1H)-one-fused 1,3,4-thiadiazole heterocyclic hybrids was achieved through structural optimization as potential antimicrobial/anti- TB agents.
source →Background Mycobacterium abscessus complex (MABC), comprising Mycobacterium abscessus subsp. abscessus (MABa), Mycobacterium abscessus subsp. bolletii (MABb), and Mycobacterium abscessus subsp.
source →Oral delivery of peptide therapeutics remains challenging due to gastrointestinal (GI) degradation and poor intestinal absorption.
source →Dupilumab, a monoclonal antibody blocking interleukin-4/interleukin-13 signaling, was associated with neuroinflammatory syndromes in 4 children treated for atopic dermatitis. Individuals exhibited behavioral changes, language impairment, and neurodiagnostic abnormalities 2-6 months after treatment initiation.
source →Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →NLRP3 functions as a critical intracellular danger sensor for inflammasome activation, playing a crucial role in autoimmune diseases. Vitiligo progression has been linked to NLRP3, yet its specific involvement in melanocytes of vitiligo remains poorly understood.
source →The pursuit of pharmacological enhancement in sport has evolved from the widespread use of anabolic-androgenic steroids (AAS) to novel agents such as peptides and peptide analogues.
source →Oral cancer ranks among the most prevalent malignant tumors of the head and neck, comprising 1%-2% of all global malignancies.
source →Background There is a concerning trend of misinformation of healthcare related content on social media. Recent studies have examined themes and narratives about Crohn's disease but have not quantitatively assessed the accuracy and quality of content on Instagram Reels.
source →Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death.
source →