Tesamorelin
aka Egrifta
Mechanism
Tesamorelin (Egrifta / Egrifta SV) is a stabilized analog of human GHRH(1-44) with a trans-3-hexenoic acid moiety at the N-terminus that protects against protease degradation. FDA-approved in November 2010 for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, it is the only FDA-approved GHRH analog for this indication. Off-label use for general body composition and visceral fat reduction in non-HIV populations is common but outside the approved label.
Identification
| CAS number | 218949-48-5 |
|---|---|
| Molecular formula | C221H366N72O67S |
| Sequence | YADAIFTNSY RKVLGQLSAR KLLQDIMSR QQGESNQERG ARARL |
| Typical dose | 2 mg/day subcutaneous (approved EGRIFTA); 1.4 mg/day (EGRIFTA SV); research use mirrors clinical dosing of 1–2 mg/day SC |
| Half-life | ~26–38 minutes (Wikipedia / literature); FDA label reports ~8 minutes (single SC dose, healthy subjects) |
Vendors selling Tesamorelin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $122.00 | — | 99 |
| Glacier Aminos | 10 mg | $67.99 | — | 99 |
| Glacier Aminos | 20 mg | $67.99 | — | 99 |
| Moglabs | 5 mg | $50.00 | — | 96 |
| BioLongevity Labs | 8 mg | $115.00 | — | 96 |
| BioLongevity Labs | 10 mg | $149.97 | — | 96 |
| Crush Research | 20 mg | — | — | 95 |
| Orbitrex Peptides | 10 mg | $69.99 | — | 95 |
| Profound Aminos | 5 mg | $59.00 | — | 95 |
| Reta One Labs | 20 mg | $92.00 | — | 95 |
| Reta One Labs | 10 mg | $39.00 | — | 95 |
| Licensed Peptides | 10 mg | $899.95 | — | 95 |
| Licensed Peptides | 10 mg | $764.95 | — | 95 |
| Licensed Peptides | 10 mg | $152.99 | — | 95 |
| Licensed Peptides | 10 mg | $130.99 | — | 95 |
| Prime Peptides | 10 mg | $60.00 | — | 95 |
| Peptide Tech | — | $36.99 | — | 94 |
| Mile High Compounds | — | $79.99 | — | 94 |
| Forge Performance Co. | 10 mg | $60.00 | — | 94 |
| Amino Club | — | $69.99 | — | 93 |
| Hydro Research Peptides | 10 mg | $0.55 | — | 91 |
| Hydro Research Peptides | 6.98 mg | $1.20 | — | 91 |
| Skye Peptides | 10 mg | $60.00 | — | 90 |
| Peptidology | 10 mg | $69.00 | — | 89 |
| Peptide Plugs | 16 mg | $90.00 | — | 89 |
| Peptide Plugs | 10 mg | $70.00 | — | 89 |
| Ruo Bio | 5 mg | $48.00 | — | 88 |
| Sunrise Bioresearch | 20 mg | $97.04 | — | 88 |
| Sunrise Bioresearch | 100 mg | $475.53 | — | 88 |
| Arcane Peptides | 5 mg | $50.00 | — | 88 |
| EZ Peptides | 10 mg | $88.00 | — | 85 |
| EZ Peptides | 10 mg | $68.00 | — | 85 |
| Simple Peptide | 2 mg | $109.00 | — | 85 |
| Simple Peptide | 10 mg | $75.00 | — | 85 |
| Peptidegurus | 5 mg | — | — | 84 |
| Peptidegurus | 20 mg | — | — | 84 |
| Reta Peptide | 10 mg | $180.00 | — | 83 |
| Ascension Peptides | 5 mg | $50.00 | — | 83 |
| Cocer Peptides | 10 mg | $160.00 | — | 82 |
| Blank Peptides | 10 mg | $75.00 | — | 81 |
| OROS Research | 10 mg | $89.99 | — | 79 |
| OROS Research | 20 mg | $129.99 | — | 79 |
| OROS Research | 5 mg | $44.99 | — | 79 |
| Texpeptide | 10 mg | $65.00 | — | 69 |
| Crystal Peptides | 5 mg | $44.99 | — | 66 |
| Crystal Peptides | 10 mg | $79.00 | — | 66 |
| Certified Peptides | 10 mg | $82.00 | — | 61 |
| Sports Technology Labs | 5 mg | $84.99 | — | 58 |
| Nox Amino | 10 mg | $75.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| Taishijie | — | — | — | 51 |
| Taikangbio | — | — | — | 50 |
| MEI-PEPETIDE | 2 mg | $51.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $81.00 | — | 43 |
| HongDa Peptide | — | $57.00 | — | 43 |
| zztai Peptide Ltd | 2 mg | $57.00 | — | 43 |
| zztai Peptide Ltd | 5 mg | $97.00 | — | 43 |
| zztai Peptide Ltd | 10 mg | $181.00 | — | 43 |
| MJT peptides | 2 mg | $57.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | — | — | — | 37 |
| BioCollex Research | — | $85.00 | — | 31 |
| Nextech Labs | 10 mg | $75.00 | — | 24 |
| Cernum Biosciences | 5 mg | $69.99 | — | — |
| Cernum Biosciences | 10 mg | $94.99 | — | — |
| NG Peptide | 10 mg | $50.00 | — | — |
| Kimera Chems | — | $41.99 | — | — |
| Welli Labs | — | $49.99 | — | — |
| synthesispeptides.io | 10 mg | $79.99 | — | — |
| Alpha Omega | 10 mg | $75.00 | — | — |
| Atomik Labz | 20 mg | $110.00 | — | — |
| Atomik Labz | 12 mg | $85.00 | — | — |
| Atomik Labz | 10 mg | $65.00 | — | — |
| Biotech Peptides | 8 mg | $90.00 | — | — |
| Biotech Peptides | 12 mg | $109.00 | — | — |
| Biotech Peptides | — | $38.00 | — | — |
| Core Peptides | 12 mg | $117.00 | — | — |
| Core Peptides | 8 mg | $90.00 | — | — |
| Core Peptides | 10 mg | $43.00 | — | — |
| Core Peptides | 5 mg | $43.00 | — | — |
| Felix Chemical Supply | 5 mg | $42.99 | — | — |
| Felix Chemical Supply | 10 mg | $54.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 8 mg | $110.00 | — | — |
| Genetic Peptide | 12 mg | $125.00 | — | — |
| Genetic Peptide | 2 mg | $35.00 | — | — |
| Genetic Peptide | 5 mg | $35.00 | — | — |
| Genetic Peptide | 10 mg | $35.00 | — | — |
| Genetic Peptide | 15 mg | $35.00 | — | — |
| Genetic Peptide | 20 mg | $35.00 | — | — |
| Lumi Peptides | — | $105.00 | — | — |
| Lumi Peptides | — | $60.00 | — | — |
| Modern Research Peptides | 5 mg | $31.99 | — | — |
| Modern Research Peptides | 10 mg | $59.99 | — | — |
| Nova Peptides | 5 mg | $49.99 | — | — |
| Nova Peptides | 10 mg | $49.99 | — | — |
| Nova Peptides | 20 mg | $49.99 | — | — |
| Oneday Compounds | 10 mg | $48.74 | — | — |
| Paramount Peptides | 10 mg | $64.60 | — | — |
| Peptide Crafters | 11 mg | $85.00 | — | — |
| Peptide Crafters | 10 mg | $65.00 | — | — |
| Peptira | — | $89.00 | — | — |
| Pepvida Labs | 10 mg | $55.00 | — | — |
| Polaris Peptides | 10 mg | $65.00 | — | — |
| S1 Research | 10 mg | $65.00 | — | — |
| S1 Research | 10 mg | $44.00 | — | — |
| Solution Peptides | 20 mg | $110.00 | — | — |
| Solution Peptides | 12 mg | $85.00 | — | — |
| Solution Peptides | 10 mg | $65.00 | — | — |
| Soma Peptides | 6 mg | $89.00 | — | — |
| Soma Peptides | 12 mg | $89.00 | — | — |
| Soma Peptides | 10 mg | $80.00 | — | — |
| Southern Aminos | 10 mg | $55.30 | — | — |
| True Peptide | 10 mg | $70.00 | — | — |
| Wellness Peptides | 5 mg | $75.00 | — | — |
| Wellness Peptides | 5 mg | $50.00 | — | — |
| Wellness Peptides | 10 mg | $50.00 | — | — |
| idunpeptides.com | — | $49.99 | — | — |
| optimasupply.is | 10 mg | $55.00 | — | — |
| realpeptides.co | — | $95.00 | — | — |
| realpeptides.co | — | $90.00 | — | — |
| rescueresearchusa.com | 10 mg | $69.99 | — | — |
Research
Background The Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH) study is a randomised controlled trial with the overall goal of examining the combined effect of exercise and the growth hormone-releasing hormone analogue tesamorelin on physical function.
source →Background Excess visceral abdominal fat (EVAF) is a prevalent metabolic complication among people living with HIV-1 (PLWH), occurring even in individuals with normal or mildly elevated body mass index (BMI).
source →The introduction of combination antiretroviral therapy (cART) has significantly reduced AIDS-related morbidity and mortality. However, the prevalence of age-associated comorbidities, particularly cardiovascular diseases (CVD), has increased, becoming a leading cause of mortality in people living with HIV.
source →Background HIV-associated lipodystrophy leads to visceral fat accumulation, metabolic complications, body image concerns, medication non-adherence, and increased cardiovascular risks.
source →Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis.
source →Cognitive decline with age and other clinical conditions are linked with reduced hypothalamic-pituitary-adrenal (HPA) axis function.
source →Background Injectable peptides are increasingly promoted for musculoskeletal recovery, tissue repair, and performance enhancements; however, clinical adoption has outpaced high-quality evidence and regulatory consensus.
source →Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance enhancement.
source →Background Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients.
source →Purpose of review People living with HIV (PLWH) on contemporary antiretroviral therapy experience high rates of overweight/obesity, which predisposes to cardiometabolic disease and multiple other conditions with negative health consequences in this aging population.
source →This randomized, double-blind, placebo-controlled Phase II study evaluates whether daily subcutaneous tesamorelin (a growth hormone-releasing hormone analog) reduces liver fat in adults with fatty liver disease.
source →Nonalcoholic fatty liver disease (NAFLD) is common in individuals with obesity and is a significant threat to public health, because it can lead to impaired liver function and liver failure. Growth hormone is a hormone produced in the pituitary gland that helps regulate metabolism and growth.
source →The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial recovery of motor and sensory function following surgical repair of injured peripheral nerves.
source →The aim of this study is to test whether tesamorelin, in combination with a text-messaging application to help with motivation and adherence, will significantly improve memory and thinking in HIV.
source →Liver disease is one of the leading co-morbidities of human immunodeficiency virus (HIV) infection, and nonalcoholic fatty liver disease (NAFLD) is present in approximately 30-40% of patients with HIV infection.
source →The purpose of this observational, 10-year, prospective cohort study is to assess the potential safety concerns of long-term exposure to EGRIFTA® in HIV-infected subjects with abdominal lipohypertrophy compared with a similar group of subjects not exposed to EGRIFTA®.
source →RCT: tesamorelin-driven visceral-fat reduction was associated with an improved metabolic profile in HIV-infected patients.
source →Review of tesamorelin in the management of HIV-associated lipodystrophy — its FDA-approved indication.
source →Pivotal RCT: tesamorelin, a GHRH analogue, reduced visceral adipose tissue in HIV-infected patients with abdominal fat accumulation.
source →The purpose of this trial is to examine the short-term effects of Growth Hormone Releasing Hormone (GHRH, tesamorelin) administration in healthy men. We hypothesize that GHRH will increase GH pulse height and will not affect insulin sensitivity.
source →The primary objective of the study is to determine the PK (tesamorelin) and PD (IGF-1) profiles of tesamorelin after a single 2 mg subcutaneous administration and after repeated administration once daily for 14 consecutive days.
source →